Article History

Received 17 August 2014
Received in revised form 20 August 2014
Accepted 25 August 2014
Available online 30 August 2014

Keywords

Paclitaxel, Di allyl sulfide, DMBA, Skin cancer.

A COMBINATION OF PACLITAXEL AND DI ALLYL SULFIDE ON THE ACTIVITIES OF MITOCHONDRIAL ENZYMES CHANGES IN 7, 12 DI METHYL BENZ(A) ANTHRACENE INDUCED SKIN CANCER WISTAR RATS

Muninathan N.1*,   P.Mohanalakshmi2, T.S. Meghalatha3 and S. Malliga4

1*Department of Biochemistry, Meenakshi medical college and RI, Kanchipuram, Tamilnadu.

2Department of Biochemistry, Sri Muthukumaran medical college and RI, Chennai, Tamilnadu.

3Department of Biochemistry, Karpaga vinayagar medical college, Chengalpet, Tamilnadu.

4Department of Biochemistry, ESIC medical college, Chennai, Tamilnadu.

*Corresponding author; muninathanpappaiya@gmail.com; Mob: +919677814596  

ABSTRACT: The purpose of this study is to investigate the changes in the levels of mitochondrial enzymes and efficacy of combination of paclitaxel along with Di allyl sulfide against skin cancer in experimental animals. Skin cancer was induced in rats by 7, 12 Di methyl benz (a) anthracene (DMBA) at the dosage of 5 g   dissolved in 100l acetone and administered into experimental animals for 28 weeks. In this study, we demonstrated that combination of paclitaxel and Di allyl sulfide revert the changes in the rats from lethal dose of DMBA within 30 days. The levels of mitochondrial enzymes in skin and liver were found to be increased in the cancer bearing animals when compared with control animals. Treatment of Paclitaxel along with Di allyl sulfide to cancer induced animals showed significant increase in the levels of mitochondrial enzymes when compared with cancer induced animals. The treatment with combination of paclitaxel and Di allyl sulfide effectively raised mitochondrial enzymes levels. So, from the obtained results it is concluded that paclitaxel and Di allyl sulfide is capable of restoring the skin architecture.

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