Article History

Received 4 April 2020
Received in revised form 16 April 2020
Accepted 18 April 2020
Available online 30 April 2020


Trigonella foenum graecum, D-galactose, free radicals, lipofuscinogenesis, antioxidative enzymes.

Protective effect of fenugreek seed extract on lipofuscinogenesis and antioxidative profile in reproductive system of aging accelerated male mice

Deshmukh V.M. 1*, Walvekar M. V.2, Ghadage Y.K. 3 and Deshpande V.Y.3

1Department of Zoology, Shivraj College, Gadhinglaj.

2Department of Zoology, Shivaji university, Kolhapur.

3Department of Zoology, Yashavantrao Chavan Institute of Science, Satara.

*Corresponding author

ABSTRACT: The free radicals play a central role in aging process and disease progression. Antioxidants are prevents the damage caused by reactive oxygen species (ROS). Fenugreek (Trigonella foenum graecum) is a leguminous plant and its seeds used in herbal medicines. The purpose of present study was to demonstrate the effect of fenugreek seed extract (FSE) on lipofuscinogenesis and antioxidative enzymes i.e. SOD (Superoxide dismutase), CAT (Catalase) and GPx (Glutathione peroxidase) in testis and accessory reproductive organs of D-galactose induced mice. For the present investigation mice (Mus musculus) were divided into six groups viz, 1) Control group received 2) D-galactose treated group 3) D-galactose + FSE (50 mg/kg BW) for 20 days. 4) D-galactose FSE (50 mg/kg BW) for 20 days. After the treatment of D-galactose showed significant increase in lipid peroxidation and decreased amount of antioxidative enzymes as compared to control group. After treatment of FSE, the lipofuscinogenesis and fluorescence product were significantly decreased while antioxidative enzymes were significantly increased in testis, Epididymis and Seminal vesicle. So, it may conclude that fenugreek seed extract acts as an antioxidative agent and its treatment effective against the oxidative damage.


Full text article in PDF