Article History

Received 04 May 2018
Received in revised form 14 May 2018
Accepted 28 May 2018
Available online 30 May 2018

Keywords

Nanoparticles, Nano-biointerphase, Nanotoxicity, ROS, NF-kB, IKK, Inflammation, DNA, RHD, TNF-alpha.

Molecular Mechanism of Nanotoxicity - A Critical Review

Arijit Chakraborty1*, Sagnik Ghosh1, Rosalind Chakraborty2, Sparsa Moni Chatterjee3 and Waheeta Hopper2

1Department of Textile Technology, Govt. College of Engineering and Textile Technology, Govt. of West Bengal, Serampore – 712 201, West Bengal, India.

2Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur-603203, Tamil Nadu, India.

3Former Vice Chancellor, Indian Institute of Engineering, Science and Technology, Shibpur, Howrah-711103, West Bengal, currently Chairman, RCC Institute of Information Technology, Govt. of West Bengal, Kolkata-700015, West Bengal.

*Corresponding author: Profarijit@rediffmail.com

ABSTRACT: In the past decades, nanoparticles have been widely used in industry and pharmaceutical fields for drug delivery, anti pathogen and diagnostic imaging purposes because of their unique physicochemical characteristics such as special ultrastructure, dispersity and effective cellular uptake properties. Hence, bio-nanotechnology has been receiving immense attention in recent years but the nanotoxicity has been raised over the extensive application of nanoparticles and despite the extensive use of nanoparticles today there is still a limited understanding of nanoparticle mediated toxicity. So, there is a dire need for a full understanding of the mechanisms by which nanoparticles bioaccumulate, intrude the skin barrier as well as interact with biomacromolecules such as protein, lipid and DNA. Literature review over the past decade reveals very scanty, sporadic and confusing molecular level descriptions of such mechanism. In this review, an attempt has been made through an exhaustive study to explore the possible molecular and cellular events responsible for nanotoxicity.

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